Human transforming growth factor beta 1 (TGF-1) is a pleiotropic cytokine involved in a wide array of cellular processes, including cell growth, differentiation, apoptosis, and immune regulation. Assays measuring the levels of this protein in biological samples are used to evaluate its role in various physiological and pathological conditions. The determination of circulating or tissue-specific concentrations of this factor can provide insights into the status of fibrotic diseases, inflammation, and certain cancers. It helps in understanding the biological mechanisms underlying these processes.
Quantifying this factor offers significant value in both research and clinical settings. In research, it serves as a biomarker to investigate the mechanisms of disease progression and the efficacy of therapeutic interventions. Clinically, elevated levels are associated with conditions such as pulmonary fibrosis, kidney disease, and certain cancers, while decreased levels may indicate immune deficiencies. Therefore, assessing its presence contributes to diagnosis, prognosis, and monitoring treatment response. The investigation of this protein has facilitated the development of targeted therapies aimed at modulating its activity, thereby improving patient outcomes.
