The detectability of psilocybin and psilocin, the psychoactive compounds present in certain fungi, through standard drug screening methodologies is a primary concern for individuals who may have ingested these substances. Standard drug tests are not typically designed to identify these specific compounds. The focus of routine drug screenings is primarily on substances like opiates, amphetamines, cocaine, and tetrahydrocannabinol (THC), among others.
The absence of routine testing for psilocybin and psilocin stems from several factors, including the relatively short duration these substances remain detectable in the body and the associated cost of developing and implementing specific assays for them. Furthermore, legal restrictions and societal perspectives influence the demand for such testing, limiting its widespread adoption. Historically, drug testing has focused on substances perceived as having broader societal impact and potential for abuse, leading to prioritization of other drug classes.