Plasma metanephrines represent metabolites of catecholamines, such as epinephrine and norepinephrine, circulating within the bloodstream. A laboratory assessment quantifying these substances, interpreted against established reference intervals, aids in evaluating adrenal gland function and detecting potential abnormalities in catecholamine production. The resulting values, when within the expected parameters, generally suggest normal catecholamine metabolism.
Evaluating concentrations of these compounds is critical for identifying conditions like pheochromocytomas and paragangliomas, tumors that secrete excessive catecholamines. Accurate interpretation of the test results is essential for proper diagnosis and treatment, preventing potentially life-threatening complications associated with uncontrolled catecholamine release. The introduction of standardized methodologies has improved the reliability and clinical utility of this diagnostic tool.