A sophisticated analytical technique widely used in clinical diagnostics and research, it combines liquid chromatography with tandem mass spectrometry. This methodology facilitates the identification and quantification of specific molecules within complex biological samples, such as serum or plasma. For example, it can precisely measure the concentration of a particular drug or metabolite circulating in a patient’s bloodstream.
Its significance lies in its high sensitivity and specificity, allowing for the detection of even trace amounts of target compounds that may be missed by other methods. This enhanced precision has revolutionized various fields, including newborn screening, therapeutic drug monitoring, and toxicology. The historical development of this technology has seen continuous advancements, improving its accuracy and expanding its applicability to a wider range of analytes.
